Why/how are you being 'forced' to use 4 NICs for storage/iSCSI??
I would also split off the vMotion traffic from the other NICs... My normal configuration is 2x Management, 2x vMotion, 2x VM and 2x iSCSI. I adjust iSCSI and VM port count according to the environment and configuration demands. I also split each port group across two network adapters/controllers so that there's no single point of failure on any of it. So, if there's two onboard NIC's and two add-on (quad port) cards, I would use one each from the onboard for management and vMotion, picking up the second for each from the two cards (not taking both ports from one card). Then I split the remaining ports on the cards so that if/when one fails, the environment remains alive/viable. I also splt the traffic from the host across multiple core switches, if there's more than one in the environment. This way, even if we lose a core switch, for some reason, the environment remains alive/viable.
