I have several external FireWire drives that each have a version of Mac OS X installed, Leopard, Snow Leopard and or Lion and at one time or another it was either a clone of an internal HDD and not necessarily the system the external drive is connected to at any given time and also clean install to the external drive. I've then had just about every version of VMware Fusion installed under each and have never had any problems installing VMware Fusion in this manner. These are all US English installs of both Mac OS X and VMware Fusion and other language installs may be problematic in some cases. Although I have to admit that off the top of my head I can't recall any language specific issues however I'm pretty sure there have been some in the past. The best place to look is the Release Notes and Knowledge base.
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